Dicarboxylic acids and derivatives
Medchemexpress LLC Rhodamine 101 chloride | 64339-18-0 | 527.05 g/mol | C32H31ClN2O3 | 10 MG
Rhodamine 101 chloride is a bright xanthene-class fluorescent dye with excitation and emission maxima at 565 nm and 595 nm, respectively. It is used for fluorescence microscopy, cellular staining, and as a red-spectrum reference standard. The solid is supplied in small laboratory pack sizes and should be stored protected from light and moisture; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Excitation 565 nm and emission 595 nm.
- Suitable for fluorescence microscopy and cellular staining.
- Useful as a reference standard in red-spectrum labeling.
- Available in small lab pack sizes, including 10 mg.
- Store sealed, protected from moisture and light.
Medchemexpress LLC 7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 50 MG
CUDC-101 is a small-molecule research inhibitor of histone deacetylases (HDACs), epidermal growth factor receptor (EGFR), and HER2, used in preclinical cancer research to assess antiproliferative and target-specific effects.
- Potent inhibitor of HDAC, EGFR, and HER2 with low-nanomolar activity.
- Demonstrates broad antiproliferative effects across cancer cell lines.
- Supplied as a light yellow to yellow powder for laboratory use.
- High purity suitable for research applications (reported ≥98% by HPLC).
- Available in small-mass packaging for research workflows.
- Molecular weight 434.49 g/mol.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.06% | 50 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment that exhibits solid-state fluorescence with excitation/emission at 411 nm/512 nm. This product is available as a commercial colorant.
- Yellow bis-azomethine pigment
- Excitation/emission: 411 nm/512 nm
- Exhibits solid-state fluorescence
- Available as a commercial colorant
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.1% | 100 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment that exhibits solid-state fluorescence and is available as a commercial colorant.
- Exhibits solid-state fluorescence
- Available as a commercial colorant
- Yellow bis-azomethine pigment
- Excitation/emission: 411 nm/512 nm
TARGETMOL CHEMICALS INC MG-101 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. purity: 98%
Medchemexpress LLC ULK-101 100mg | 2443816-45-1 | 100 MG
ULK-101 is a potent and selective ULK1 inhibitor used in research to suppress autophagy and sensitize cancer cells to nutrient stress. It demonstrates high potency against ULK1 with reduced activity against ULK2.
- Selective ULK1 inhibition with IC50 ≈ 1.6 nM.
- Reduced activity against ULK2 (IC50 ≈ 30 nM).
- High chemical purity reported at 99.91%.
- Molecular formula C22H16F4N4OS and molecular weight 460.45.
- Supplied as a powder; common pack size 100 mg.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | 95.0% | 563.51 | 25 MG
Rhodamine 101 hydrochloride is a fluorescent dye. It is known for its bright fluorescence and specific excitation and emission characteristics.
- Exhibits bright fluorescence
- Excitation maxima at 565 nm
- Emission maxima at 595 nm.
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | MFCD00210089 | >=95% | 563.51 | 5 MG
Rhodamine 101 chloride (Rhodamine 640 chloride) hydrochloride is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.
- For research use only.
- We do not sell to patients.
Apexbio Technology LLC Sulforhodamine 101 60311-02-6 25mg
Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
Medchemexpress LLC PKUMDL-LC-101-D04 500mg | 2143896-83-5 | 378.93 g·mol⁻¹ | C14H23ClN4O2S2 | 500 MG
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research on ferroptosis, lipid peroxidation, and inflammation. It increases GPX4 enzymatic activity in cell-free and cellular assays (reported pEC50 = 4.7) and protects cells from cholesterol peroxide-induced toxicity.
- Allosteric activator of GPX4, reported pEC50 = 4.7.
- Increases GPX4 activity to ~150% in cell-free and cellular extracts at reported concentrations.
- Demonstrated inhibition of ferroptosis and protection against lipid peroxide-induced cell death.
- Molecular weight ~378.93 g·mol⁻¹ and chemical formula C14H23ClN4O2S2.
- Supplied as a high-purity research chemical suitable for biochemical and cellular assays.
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 1 MG
UK-101 is a selective small-molecule inhibitor of the immunoproteasome β1i (LMP2) subunit used in biochemical and cellular research to probe immunoproteasome function and induce apoptosis in certain cancer models.
- Selective LMP2 (β1i) inhibitor with reported IC50 of 104 nM.
- Shows ~144-fold selectivity versus β1c and ~10-fold versus β5.
- High reported purity (99.58%) suitable for research applications.
- Molecular weight 484.74 g·mol⁻¹ and formula C25H48N2O5Si.
- Soluble in DMSO and supplied in small research quantities, including 1 mg packs.
Medchemexpress LLC AVN-101 hydrochlorid 25mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 25 MG
AVN-101 hydrochloride is the hydrochloride salt of a brain-penetrant small molecule antagonist of serotonin (5-HT) receptors, supplied for preclinical and in-vitro research. It is provided as a solid with reported high purity for analytical and biological assays.
- Potent antagonist of 5-HT receptor subtypes (5-HT7, 5-HT6, 5-HT2A, 5-HT2C).
- High purity: 99.59%.
- Molecular formula C21H25ClN2; molecular weight 340.89.
- Available in small research pack sizes, including 25 MG.
- Provided as hydrochloride salt to improve solubility for assay preparation.
- For research use only; not for human or veterinary use.
Selleck Chemical LLC PHI-101-E1437-25MG
PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)